The groups of Dr. Qiuwei Abdullah Pan (Erasmus Medical Center, the Netherlands) and Dr. Wenshi Wang (Xuzhou Medical University, China) are jointly recruiting several postdocs to work on hepatitis E, with specific interests in studying virus-host interactions and therapeutic development mainly using human organoids based models, as well as epidemiology and public health of hepatitis E. It is also possible to work on other viral diseases such as hepatitis D, coronaviruses, monkeypox, and flaviviruses.
For more information, please contact Dr. Qiuwei Abdullah Pan (q.pan@erasmusmc.nl), and Dr. Wenshi Wang (wenshi.wang@xzhmu.edu.cn).
Selected references:
Li P, Li Y, Wang Y, Liu J, Lavrijsen M, Li Y, Zhang R, Verstegen MMA, Wang Y, Li TC, Ma Z, Kainov DE, Bruno MJ, de Man RA, van der Laan LJW, Peppelenbosch MP, Pan Q. Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Sci Adv. 2022 Jan 21;8(3):eabj5908.
Li Y, Zhang R, Wang Y, Li P, Li Y, Janssen HLA, de Man RA, Peppelenbosch MP, Ou X, Pan Q. Hepatitis E virus infection remodels the mature tRNAome in macrophages to orchestrate NLRP3 inflammasome response. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304445120.
Ding Y, Guo H, Hong X, Li Q, Miao Z, Pan Q, Zheng K, Wang W. The distinct spatiotemporal evolutionary landscape of HBV and HDV largely determines the unique epidemic features of HDV globally. Mol Phylogenet Evol. 2024 Aug;197:108114.
Guo H, Li Q, Li C, Hou Y, Ding Y, Liu D, Ni Y, Tang R, Zheng K, Urban S, Wang W. Molecular determinants within the C-termini of L-HDAg that regulate hepatitis D virus replication and assembly. JHEP Rep. 2023 Nov 15;6(1):100961.
Wang W, Lempp FA, Schlund F, Walter L, Decker CC, Zhang Z, Ni Y, Urban S. Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates. J Hepatol. 2021 Aug;75(2):311-323.
Li P, Pachis ST, Xu G, Schraauwen R, Incitti R, de Vries AC, Bruno MJ, Peppelenbosch MP, Alam I, Raymond K, Pan Q. Mpox virus infection and drug treatment modelled in human skin organoids. Nat Microbiol. 2023 Nov;8(11):2067-2079.
